Modulation of gastrointestinal bacterial in chronic atrophic gastritis model rats by Chinese and west medicine intervention

Abstract Chronic atrophic gastritis (CAG) is well-known related with multiple pathogenic factors and normally therapies comprised by western or Chinese medicines. The present study was designed to identify the bacterial community characterized 16S rRNA amplicon sequencing determine modulate affection of composition response medicine Qinghuayin (QHY) as well antibiotic on model rats. result shown overall structure alteration appeared under intervened, caused a marked depletion in diversity richness. enrichments Firmicutes (85.1–90.7%) antibiotic-free converts into Bacteroidetes (30.7–34.6%) antibiotic-added rat were demonstrated. most dominant phylum treatments significantly decreased till 21.9–68.5% treatments. Especially QHY-treated rats showed highest RA (90.7%) amelioration CAG using QHY attributed beneficial enrichment, especially Ruminococcus , Lactobacillus Bifidobacterium . In addition, alpha beta analysis also demonstrated clear dispersion aggregation that revealed steady structures. summary, has potential application value treatment CAG, which close relation modulatory internal communities.